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Erectile Function and Viagra
In healthy men sildenafil increased sensitivity to nitroglycerin, an exogenous NO donor, approximately 4-fold but did not affect endothelium-dependent, NO-mediated responses in either the hand vein or forearm vasculature
The Physiology of Nitric Oxide
Nitric oxide dilates blood vessels, raising blood supply and lowering blood pressure. Conversely, it helps protect tissues from damage due to low blood supply. Also a neurotransmitter, nitric oxide acts in the nitrergic neurons active on smooth muscle, abundant in the gastrointestinal tract and erectile tissue.
Why was the Nobel Prize awarded for Nitric Oxide?
The Nobel Prize in Physiology or Medicine for Nitric Oxide was awarded in 1998 to three pharmacologists working independently. The title of the Nobel Prize was “Nitric Oxide as a Unique Signaling Molecule in the Cardiovascular System”
The History of the Discovery of Nitric Oxide
By 1989 both the biosynthesis and mechanism of action of NO were elucidated. It became clear that NO is a signaling molecule produced enzymatically from L-arginine and then immediately activates cytosolic guanylate cyclase by heme-dependent mechanisms to elevate cyclic GMP.
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